Of course there is scores of different lores one could follow in interpretting the combat prowess of the relative contenders. We could pick the highest end Lumley Vampire who can forge monsters through flesh and is virtually unkillable even if completely dismembered vs some wanky twilight incarnation of a werewold which I assume would be a piss weak critter.
The most popular and well constructed lore that includes both that I know is World of Darkness in which both are very very powerful beings and physically a Vampire stands a flat rating zero change against a Werewolf.
As far as we can assume across the vast majority of lores the vampire would still need to go so far as be prepared and properly equiped to kill a werewolf, a werewolf would not have to go so far.
So hey providing the vampire has got his Wolfie hunting kit, sure he may have the edge but if they are heading out too dinner on a full moon and cross paths unprepared, down goes fangy.
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