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Our last dog had a condition where all of her fluids were draining into her chest cavity. we didnt notice it until it was too late, although we went ahead and tried anyway to treat it. It was awful and almost killed my wife, she adored that dog. Some types of pets have to get beyond saving before they show that somethign is wrong. Dogs and rats are two i can think of off the top of my head. they are stoic and wont let on that something is wrong.
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