I use a program called Spyware Doctor. You can download it for free and run a scan, but you'll have to register it (for 35 bucks) for it to remove the malware/spyware it finds.
But, I will attest to its effectiveness; the first time I ran it, it found over one hundred and twenty spyware/malware objects that neither Spybot S&D nor Adaware picked up. I've been using it for about three years now, and I've yet to encounter a better spyware/malware remover. It also provides an On-Guard function and will alert you if you're entering a site which may potentially contain harmful content. It also locates and removes trojans, BHO's and CWS.
Also of use is a program called CCleaner, which cleans all temporary files from you computer. And as for a good anti-virus program, I recommend Avast! anti-virus. You can get both from
www.download.com. Both CCleaner and Avast! are totally free.
Funny thing is, even though Avast is totally free, it's way better than Norton or McAfee and located viral activity on my computer that neither Norton nor McAfee picked up on.