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I'd say the whole AIDS epidemic thing would be a contender for the top5 up in here...While nobody seems sure of the exact point of time in which it STARTED, it was (as I recall) sometime in the 80's that the world became aware of how truly big it was. The panic, the confusion, the association...definately changed things.
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It's not the bullet with your name on it you have to worry about...it's all those other ones marked
"to whom it may concern."
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