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If you do some research and draw off Native American shapechanging traditions , a werecougar might be very feasible. The trick then would be trying to explain the disease as a spiritual/physical change. If you examine shamanism a little, you see that a shapeshifter would just be outwardly assuming a sort of totemic true shape. Hamilton's shapeshifting traditions and connections to folklore are sorta spotty. A werecreature is often just another thing to be. Keep in mind the situation's only as interesting as the person going through it, and that the two should be playing off each other. Hamilton sort of pisses me off in that way. Everybody sooner or later just works out to be their species. It makes supernatural things a lot more banal.
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